| Jan Saenredam (1565 - 1607) | | Dutch engraver and draftsman |
| Pieter Saenredam (1597 - 1665) | | Dutch painter and draftsman |
| Jacob Ferdinand Saeys (1658 - 1725) | | |
| Cornelis Saftleven (1607 - 1681) | | Dutch draftsman and painter |
| Herman Saftleven (1609 - 1685) | | Dutch painter, draftsman, and printmaker |
| Pierre Le Sage (active 1763-1796) | | French miniaturist active in the Netherlands |
| Giovanni Battista Salvi (1609 - 1685) | | Italian painter |
| Francesco Salviati (1510 - 1563) | | Italian painter and draftsman |
| Paul Sandby (1731 - 1809) | | English artist and architect |
| Jan Sanders van Hemessen (c. 1519 - 1556) | | Early Netherlandish painter |
| Joachim von Sandrart (1606 - 1688) | | German painter, printmaker, and writer |
| Frederick Sandys (1829 - 1904) | | English painter, illustrator, and draftsman |
| Girolamo da Santa Croce (1480 - 1556) | | Italian painter |
| Jean-Baptiste Santerre (1651 - 1717) | | French painter |
| Giovanni Santi (1430 or 1440 - 1494) | | Italian painter |
| Rubens Santoro (1859 - 1942) | | Italian painter |
| Dirck Dircksz. van Santvoort (1610/11 - 1680) | | Dutch painter |
| Carlo Saraceni (c. 1580 - 1620) | | Italian painter |
| John Singer Sargent (1856 - 1925) | | American painter |
| Andrea del Sarto (1486 - 1530) | | Florentine painter |
| Francis Sartorius (1734 - 1804) | | |
| John Nost Sartorius (1759 - 1828) | | English painter |
| William Sartorius (active ca. 1773-1779) | | British painter |
| Giovanni Battista Sassoferrato (1609 - 1685) | | |
| Salomon Saverij (1594 - 1678) | | Dutch printmaker and publisher |
| Jacob Savery (c. 1545 - 1602) | | Dutch painter and printmaker |
| Roelandt Savery (1576 - 1639) | | Flemish draftsman, painter, and printmaker |
| Giovanni Girolamo Savoldo (active 1506 - 1548) | | Italian painter and draftsman |
| Karel van Savoy (1619 - 1665) | | Flemish painter and draftsman |
| Andrea Scacciati (1642 - 1710) | | Italian still life and flower painter |
| Simon Schaasberg ( - after 1794) | | Dutch painter, miniaturist, and silhouette artist |
| Godfried Schalcken (1643 - 1706) | | Dutch genre and portrait painter |
| Jean-Frédéric Schall (1752 - 1825) | | French painter |
| Ary Scheffer (1795 - 1858) | | Dutch painter and sculptor, active in France |
| Andreas Schelfhout (1787 - 1870) | | Dutch painter |
| Willem Schellinks (1627 - 1678) | | Dutch painter, draftsman, and etcher |
| Petrus van Schendel (1806 - 1870) | | |
| Andrea Schiavone (c. 1500 - 1563) | | Italian painter, printmaker, and draftsman |
| Egon Schiele (1890 - 1918) | | Austrian painter |
| Friedrich Schiller | | |
| Karl Friedrich Schinkel (1781 - 1841) | | German architect, painter, and printmaker |
| Johannes Pietersz. Schoeff (1608 - after 1666) | | Dutch painter |
| Mathys Schoevaerdts (c. 1665 - after 1702) | | Flemish painter |
| Hendrik Jacobus Scholten | | |
| Martin Schongauer (c. 1450 - 1491) | | Alsatian painter and engraver |
| Floris Gerritsz. van Schooten (c. 1585 - after 1655) | | Dutch painter |
| Aert Schouman (1710 - 1792) | | Dutch 18th-century painter |
| Martinus Schouman (1770 - 1848) | | Dutch marine painter |
| Adolf Schreyer (1828 - 1899) | | German painter |
| Otto Marseus van Schrieck (1619/20 - 1678) | | Dutch painter |
| Cornelis Schut (1597 - 1655) | | Flemish painter and printmaker, active in Italy |
| Johann Georg Schwartze (1814 - 1874) | | Dutch painter |
| Thérése Schwartze | | |
| Hendrik Willem Schweickhardt (1746 - 1797) | | German painter and printmaker |
| Moritz von Schwind (1804 - 1871) | | Austrian painter and illustrator |
| Kurt Schwitters (1887 - 1948) | | |
| Jan van Scorel (1495 - 1562) | | Dutch painter |
| Samuel Scott (c. 1702 - 1772) | | English painter |
| William Bell Scott (1811 - 1890) | | British painter and author |
| Henri Le Secq | | |
| Enoch Seeman the Younger (c. 1690 - 1744) | | English painter |
| Giovanni Segantini (1858 - 1899) | | Italian painter, active in Switzerland |
| Hercules Segers (1589/90 - 1633/38) | | Dutch painter |
| Daniel Seghers (1590 - 1661) | | Flemish painter |
| Gerard Seghers (1591 - 1651) | | Flemish painter |
| Hercules Seghers (1589 or 1590 - c. 1638) | | Dutch painter |
| Jakob Seisenegger (1505 - 1567) | | German painter |
| Jacopo del Sellaio (1441 - 1493) | | |
| John Thomas Serres (1759 - 1825) | | English painter |
| Paul Sérusier (1864 - 1927) | | French painter and theorist |
| Cesare da Sesto (1477 - 1523) | | Italian painter |
| Georges Seurat (1859 - 1891) | | French painter and draftsman |
| Christian Seybold (1690 or 1697 - 1768) | | German painter |
| James Seymour (c. 1702 - 1752) | | English painter and draftsman |
| William Shakespeare | | |
| Martin Archer Shee (1769 - 1850) | | Irish painter and writer |
| Jan Siberechts (1627 - c. 1703) | | Flemish painter, active in England |
| Gijsbert Sibilla (1598 - 1655) | | Dutch painter |
| Walter Sickert (1860 - 1942) | | German-born English Impressionist painter |
| Elizabeth Eleanor Siddal (1829 - 1862) | | English model, painter, and poet |
| Paul Signac (1863 - 1935) | | French painter |
| Luca Signorelli (c. 1441 or 1450 - 1523) | | Italian painter and draftsman |
| Adam Silo (1674 - 1760) | | Dutch painter, etcher, and writer |
| Louis de Silvestre (1675 - 1760) | | |
| Francesco Simonini (1686 - 1753) | | |
| Geertgen tot Sint Jans (ca. 1460 - ca. 1490) | | Early Netherlandish painter |
| Alfred Sisley (1839 - 1899) | | French and British painter |
| Karel Slabbaert (1618/19 - 1654) | | Dutch painter and etcher |
| Max Slevogt (1868 - 1932) | | German painter and printmaker |
| Pieter Cornelisz. van Slingelandt (1640 - 1691) | | Dutch Golden Age portrait painter |
| John Sloan (1871 - 1951) | | |
| Claus Sluter (ca. 1360 - before 1406) | | Netherlandish sculptor |
| John Smibert (1688 - 1751) | | American painter |
| Aernout Smit (1641/42 - 1710) | | Dutch painter |
| Pieter Snayers (1592 - 1667) | | Flemish battle and hunt painter |
| Frans Snyders (1579 - 1657) | | Flemish painter |
| Hendrik Snyers (c. 1612 - after 1647) | | |
| Peeter Snyers (1681 - 1752) | | Flemish genre and portrait painter |
| Il Sodoma (1477 - 1549) | | Italian painter |
| Gerard Soest (c. 1600 - 1681) | | |